Pharmacologic and Genetic Manipulation of Metabolism

Jochen Seufert ORCiD

Faculty of Medicine and Medical Center – Department of Medicine II (Endocrinology and Diabetology)

RESEARCH: Glucose Metabolism, Endocrine Pancreas Regeneration and Signal Transduction, Stem Cell Biology, Adipose Tissue Biology, Type 1 Diabetes, Type 2 Diabetes, Gestational Diabetes, Obesity, Incretin Hormones, Clinical Trials in Diabetes and Metabolism, Novel Diabetes Medications, Insulin Research, Cardiovascular Disease, Inflammation, NAFLD

METHODS: Cell Biology, Animal Models for Obesity and Diabetes, Pharmacologic and Genetic Manipulation of Metabolism, Clinical Trials in Patients, Endoscopic bariatric interventions

TECHNOLOGIES: Clinical Trial Unit, Phase I-IV, Glucose Clamps in Animals and Humans

Clinical Trials: EFFORT, SCORED, COMBAT-T2-NASH

Robert Zeiser ORCiD

Faculty of Medicine and Medical Center – Internal Medicine I (Hematology and Oncology)

RESEARCH: Immunometabolism, Cancer Immunotherapy, Allogeneic Stem Cell Transplantation, Graft-versus-Host Disease, Oncogenic Signaling

METHODS: Pharmacologic and Genetic Manipulation of signaling in tumor cells, animal models for acute leukemia and melanoma, Metabolism, Extracellular Metabolic Flux Analysis, bioluminescence imaging

Ian Gentle ORCiD

Faculty of Medicine and Medical Center – Institute for Microbiology and Hygiene

RESEARCH: Immunometabolism, Cancer Metabolism, Mitochondria, Innate Immune Sensing, Macrophages, Signal Transduction, Cell Biology, Cell Death, Inflammation, Crosstalk between cell death signalling and metabolism, Authophagy, metabolic regulation of transcription factors in AML

METHODS: Pharmacologic and Genetic Manipulation of Metabolism, Fluorescence microscopy, Extracellular Metabolic Flux Analysis, CRISPR-Cas9

Felicitas Bucher ORCiD

Faculty of Medicine and Medical Center – Eye Center

RESEARCH: Signal Transduction, Metabolic Signalling, Mitochondria, Cell Biology, Angiogenesis, Retinal Vasoproliferative Disease

METHODS: Pharmacologic Manipulation of Metabolism, Extracellular Metabolic Flux Analysis (via collaboration), mouse models of retinal vasoproliferative disease (mouse model of oxygen-induced retinopathy, VLDLR Knockout mouse model, Laser-CNV model), RNAseq analysis (outsourced), untargeted Metabolomics (via collaboration)

Olaf Groß ORCiD

Faculty of Medicine and Medical Center – Institute of Neuropathology

RESEARCH: Immunometabolism, Cancer Metabolism, Metabolic Signalling, Mitochondria, Innate Immune Sensing, Macrophage Signal Transduction and Cell Biology, Cell Death, Inflammatory, Infectious, Cardiovascular and Nervous System Diseases

METHODS: Pharmacologic and Genetic Manipulation of Metabolism, Extracellular Metabolic Flux Analysis, Small Molecule Screening, Untargeted Metabolomics by MS and NMR (outsourced and via collaborations)

TECHNOLOGIES: Seahorse XFe96 Flux Analyzer (Agilent), Hypoxic Workstations i2 and H35 (Whitley), Multidrop Reagent Dispenser (Thermo)

Ralf Baumeister ORCiD

Faculty of Biology and Medicine – Institute of Biology 3, Bioinformatics and Molecular Genetics, ZBMZ

RESEARCH: Signaling mechanisms responding to stress and nutrients, ageing and age-related disesases, molecular genetics and biochemistry, C. elegans models of diseases. mTORC1 and mTORC2, SGK-1, signaling mechanisms in tumor biology, programmed cell death, autophagy

METHODS: Genetic dissection of signaling pathways, C. elegans models of human diseases, large scale RNAi screenings, protein interaction studies, DNA and RNA binding, stress biology

TECHNOLOGIES: genome-wide RNAi screenings, mutant screenings, hypoxia chamber, confocal microscopy, C. elegans robotics

Maria Stella Carro ORCiD

Faculty of Medicine and Medical Center – Department of Neurosurgery

RESEARCH: Epigenetic regulation of fatty acids synthesis enzymes, Cancer Metabolism, Regulation of lipids uptake, Hypoxia, Mesenchymal transformation in glioblastoma, Epigenetics, Tumor invasion and migration, Regulation of protein cleavage, Tumor angiogenesis.

METHODS: Pharmacologic and Genetic Manipulation of lipid synthesis enzymes, Gene expression analysis by RNAseq and qPCR, Identification of protein-protein interaction, Mice xenografts

TECHNOLOGIES: Seahorse XFe96 Flux Analyzer (Agilent), Hypoxic Workstations i2 and H35 (Whitley)

Dennis Wolf ORCiD

Faculty of Medicine and Medical Center – Cardiology and Angiology I, Vascular Immunology Laboratory

RESEARCH: Acquired Metabolic Disease, Metabolic Signalling, Immunometabolism, Adaptive Immunity, T cells, Signal Transduction, Cell Biology, Inflammatory Diseases, Cardiovascular Diseases, Apolipoproteins, Autoimmunity

METHODS: Flow Cytometry, CyTOF, single cell RNA-sequencing, clinical studies, Pharmacologic and genetic manipulation of metabolism, Transcriptomics

TECHNOLOGY: Comprehensive Lab Animal Monitoring System (CLAMS)